Excerpted from  MJWellness.com  04.13.16

The human endocannabinoid system plays a significant role in regulating our emotional state, sense of well-being and a healthy equilibrium. Cannabinoid receptors (CB1s) are located in the brain, CB2 receptors are found in peripheral organs, the gut and the immune system. These receptors can be unlocked through the release of the endogenous endocannabinoid Anandamide which has a structure very similar to that of tetrahydrocannabinol, the active constituent of cannabis. It is messenger molecule that plays a role in many bodily activities, including appetite, memory, pain, depression, and fertility – hence its name, which is derived from the word ‘ananda’ which means ‘extreme delight’ or ‘bliss’ in the Sanskrit language. Anandamide’s discovery may lead to the development of an entirely new family of therapeutic drugs.

It was isolated and its structure was first described by Czech analytical chemist Lumír Ondřej Hanuš (picture, right) and American molecular pharmacologist William Anthony Devane in the laboratory of Raphael Mechoulam at the Hebrew University of Jerusalem, Israel in 1992. Source: http://www.chm.bris.ac.uk/motm/anandamide/ananh.htm 

According to the Israeli research, the anxiety side-effect of marijuana greatly depends on the dosage. While micro-dosing brings emotional relief, higher doses increase the anxiety state.

At the same time, high-CBD strains do not have this side-effect at all, no matter what dosage you choose. It is already known that CBD blocks some of the side-effects of THC, but over the last five years, some more studies were conducted that confirmed that the CBD compound could not only decrease the negative effects but also reduce the anxiety caused by other reasons.

That is why low-THC/high-CBD strains can be used in this situation with less danger of having undesirable consequences. Though, as always in this kind of situations, you should not follow the advice blindly, you should always try and experiment in order to find a perfect weed for your own unique case.

3 The Kings is a well-balanced hybrid strain that takes best from both indica and sativa weed. This strain can bring you a pleasant high without the sedative effect. Therefore, it is suitable for consuming during the day. 3 The Kings is very good for calming your stress and depression—you can notice the changes already after the first puff.

Ash stands for Afghan Skunk Haze, and though it is an indica-dominant strain, with micro-dosing it treats anxiety better than some sativa strains. Ash provides you with both an energized and calm state, so it is enough to make just one or two puffs and feel its slightly spicy flavor, and the weed will change your mood for the better.

Cannatonic is a balanced strain with a high level of myrcene terpene that is responsible for mind relaxation. It can effectively alleviate your anxiety and panic attacks and make you feel elated. It can be a bit sedative, so beware of the dosage.

Granddaddy Purple is a popular indica hybrid that you can find in almost every dispensary. Just a few puffs will relax your body and mind, releasing your head from all the worries and tension. It is also good for those who experience insomnia and chronic pain.

Jack Herer is actually a high-THC strain, but it can help calm your stress not only with micro-dosing but with average doses as well. It could be that this effect comes from one of Jack’s parents—Northern Lights. In any case, Jack Herer brings you a calm elevating state, helps clear your head from negative thoughts, and stimulates motivation and productivity.

Just like the video game hero, Duke Nukem strain is effective in killing all the enemies of your well-being. It can not only reduce your stress and anxiety state but also alleviate headaches, migraines, muscular pain, and ocular ailments. Duke Nukem provides a very strong stoned effect, so it would be wise to consume it either in the evening or during the weekend.

Though Nebula is a hybrid strain, it works like most of the sativa herbs. With every puff, the honey aroma and flavor will fill both your body and your mind, making you more and more relaxed. If you do not want to experience the high effect, you may stop at 3-5 puffs.

The famous Skunk #1 is a really good option for easing any kind of mood disorders, whether it is depression, anxiety, panic attack, or PTSD. It is also often prescribed as an additional remedy for insomnia and chronic pain.

Special K is another high-THC strain that you should consume very carefully if you only want to get the medical effect but not get stoned. With just one puff, you will feel your body relax, your mind clear, and your state elevate.

Tangerine Haze is a typical sativa-dominant hybrid that is often prescribed for treating emotional disorders, depression, and PMS. With its tangerine smell and flavor, this strain produces a strong sedative effect if consumed in high doses and an uplifted, happy mood when lower doses are used.

Source:  https://mjwellness.com/does-weed-help-with-anxiety-top-ten-strains-to-relieve-symptoms